The Effect of Valproate Sodium on the Electrical Activity of Helix aspersa F1 Neurons in a Pentylenetetrazole-Induced Epileptic Model Using an Intracellular Recording System

Background: Epilepsy is a chronic central nervous system disorder with high prevalence in modern society. Despite using common anticonvulsant drugs, its control not adequately achieved. Animal models for seizures play the leading role advancing our understanding of cellular mechanisms epilepsy. The present study was an attempt to elucidate electrophysiological mechanism effect sodium valproate on model Understanding this drug may help clarify pharmacological screening other drugs. Methods: intracellular recording made from F1 cells garden Helix aspersa presence Ringer solution. Following extracellular application at concentration 10 mM after and before use (25mM) epileptogenic agent (pentylenetetrazol (PTZ)), we evaluated paroxysmal depolarization shift (PDS) characteristics. Results: These results showed that could reduce neuronal excitability. It significantly hyperpolarize rest action potential by decreasing frequency firing rate increasing amplitude afterhyperpolarization (AHP) can prevent PTZ. Conclusions: suggested PTZ-induced hyperexcitation hyperpolarization resting membrane (RMP), reduction AHP amplitude, frequency.